Creatine | Creatine Dosage & Benefits

Whether you’re just starting to get into fitness or you’re a gym addict, creatine is a supplement you will have most likely heard of, but what is it actually and what does it do? Other than our favorite supplement, whey protein, creatine is the most researched and scientifically studied supplement on the market, so much so that claims regarding this supplement are endorsed by the European Food Standards Agency. 

Despite this fact, many gym-goers still don’t have a knowledge of what creatine is and how it should fit into their training regime. This article aims to clear up some of your most commonly asked questions and shed light on some misconceptions.

Jump to:

What is Creatine?

What does Creatine do and how does it work?


Creatine for Women

When to take it


Side Effects

Which are the best Creatine supplements?




What is Creatine? 

When it comes to supplements, we sometimes go off hearsay, not fully understanding what we are putting into our bodies. But an understanding of supplements – what they are and why you are consuming them – is very important. 

Creatine is actually a chemical compound that occurs and can be synthesized directly in the body. It is used to supply the muscles with a particular type of energy called adenosine triphosphate (ATP). It is a combination of three different amino acids: glycine, arginine and methionine, and is naturally synthesized when we consume foods such as red meat and fish. There are however no significant dietary sources for vegetarians. 

ATP is used rapidly during exercise and therefore not only are demands increased, but stores also need to be replenished. An increase in creatine demand can be difficult to achieve from your diet alone, which is why supplementation is usually recommended. 

Consuming creatine monohydrate can enhance the storage and availability of creatine phosphate in the body so it is readily available to make more ATP during exercise.  


What does Creatine do & how does It work? 

The path that creatine takes once consumed in the body is referred to as the phosphocreatine (PCr) system. It is generally used to describe its involvement in “high-energy phosphate” metabolism of cells and tissues with high-energy demands. 

Creatine is mainly found in fast-twitch skeletal muscles. For those who consume it in large quantities, a large pool of PCr is available for immediate regeneration of ATP stores during short periods of intense activity. 

Also, during high-intensity exercise, the high creatine activity in these muscles means that the creatine-to-ATP reaction remains in a near-equilibrium state. It then enables the body to almost constantly maintain a supply of energy (over several seconds). During intense exercise, the additional creatine essentially donates the extra energy to power our cells, and this in turn reduces the rate at which we fatigue. 



1. Power, Strength and Muscle Increase

The phosphocreatine system acts to provide the main source of energy for sporting activities requiring short bursts of high-intensity exercise, making creatine the most useful, must-have supplement when it comes to sporting activities such as weight training, sprints and those using explosive movement. 

Due to a large number of scientific studies that have been performed observing the effects of creatine, there is a whole host of evidence that illustrates how this useful supplement can boost performance, strength and power through various mechanisms. Because creatine is a fuel source; it’s your body’s first choice of energy when performing anaerobic exercise (such as running or cycling). By supplementing with it, you can act to increase creatine stores, providing your body with more energy for your training. In turn, this can allow you to lift heavier weights and increase the number of repetitions you can complete. 

By pushing your body that little bit further, extra micro tears in your muscles can occur (the ache that you feel in your muscles from training). Once repaired, your muscles will build bigger, faster and stronger.


2.Improved Aerobic Capacity

Another benefit of creatine supplementation is that it can act to improve aerobic capacity (how able your heart and lungs are to supply your muscles with oxygen). For example, a study in 1997 investigated the effect of creatine consumption on anaerobic exercise capacity. 

In the study, 26 people were assigned to ingest either 5g creatine 4 times a day or a placebo (artificial sweetener) for 5 days. Each day the subjects were exercised to exhaustion. The time to exhaustion was revealed and increased and increased vo2 max (the optimum rate at which the body can effectively use oxygen) for up to 7 days after participants were supplemented with creatine. 


3. Weight Loss

Creatine is not specifically a weight loss product, however, supplementing with creatine can increase your exercise workload and therefore increase the number of calories burned. 

As well as this, by increasing lean muscle mass, creatine can act towards increasing your metabolism (the body’s process of converting food into energy).  However, while creatine may help you to lose weight by increasing your muscle mass, it is not a magic diet pill. You will only be able to lose weight if you are pushing yourself and exercising regularly. 


Creatine for Women 

Another question associated with creatine is who it is suitable for, and is it suitable for women? The benefits of creatine mean it can be effective in all kinds of individuals; from gym-goers, sprinters and cyclists, to bodybuilders, powerlifters and vegetarians. 

For women, the structure and force potential of muscle fibers is identical to that of men. This means the effects of creatine monohydrate on muscle tissue adaptation and ATP production are exactly the same for men and women! 

When to Take Creatine 

The next question we are often faced with is when to take creatine. There are some disagreements concerning the best time to take it, and whether you should be consuming it before or after a workout. 

Supplementing with creatine before a workout is based on the idea that, the greater the creatine concentration in muscles, the more ATP energy is available, meaning you can achieve a greater level of power during your workouts. This therefore allows you to sprint faster or lift more weight, so even more muscle can be gained. 

However, during a workout, the body’s natural supply of creatine is easily depleted. It is therefore suggested to consume it post-workout. This can help to replenish your muscles and allow you to continue receiving all of the great benefits. This is especially the case when creatine is consumed in conjunction with carbs. It is thought that it should be taken with simple sugars like dextrose and alpha lipoic acid in order to elicit an insulin response — which can result in more creatine being transported to the muscles. 

Generally, it is recommended to consume creatine after a workout, with the next best option being first thing in the morning, prior to a workout.



In the body, the liver produces approximately 2-3g of creatine per day and we can also find low concentrations in red meat, however, supplementing with extra can significantly increase the concentration of creatine in the muscles, so how much should we take? 

Generally, two doses of 3-5g per day is recommended for 2 to 6 weeks, alongside a good weight training regime and diet. However, there is still a lot of debate surrounding the creatine loading phase and whether or not this is necessary.


Creatine Loading 

According to some studies that have addressed this question, going through a loading phase appears to be an effective and fast way to increase the amount of muscle phosphocreatine. Creatine loading involves supplementing with large doses of creatine, such as 20g for around 5 days, in order to fully saturate the muscles’ phosphocreatine content. This loading phase is then followed by a maintenance phase, whereby supplementation is reduced to a single, daily dose of 5g. 

For example, the International Society of Sports Nutrition states that the quickest way to increase muscle creatine content is to consume 0.3g per kg body weight for at least the first 3 days, followed by a maintenance period of 3 to 5 grams per day. 

Conversely, other studies, state that a creatine “load” in skeletal muscle of humans can be achieved by ingesting 20g for 6 days. Alternatively, the ingestion of 3g per day over a minimum period of 4 weeks is also likely to be as effective at raising tissue levels as loading- just at a slower rate.

Find out more about the creatine loading phase in our article below.

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Side Effects 

Over the years there has been a range of anecdotal side effects of creatine supplementation reported. These include digestive issues, cramping and dehydration. However, scientific studies haven’t backed up these claims. 

The main side effect is weight gain caused by water retention. 


Water Retention 

Creatine is an osmotically active substance which means it draws water into your muscle cells. This results in an increase of total body weight. This is may be more profound if you are following a loading protocol with reports of some increasing body mass by as much as 4.8kg after a week of creatine loading.

It is important to understand that such large, short term increases in body mass are down to water retention rather than fat or muscle gain. 

It has also been said that the swelling in the muscle caused by water retention may act as a signal that switches on muscle protein synthesis. This may eventually lead to more muscle in the long term.

Once the creatine cycle is complete, the water weight from your muscles should be lost within 2 weeks. 



There have been some reports of long-term supplementation affecting renal function and whilst studies have shown that there is little risk, it’s best for those with renal conditions to consult with your doctor before using creatine. 

For healthy people, long term supplementation (30g/d for 5 years) has been shown to have no adverse effects on the kidneys. 


The best creatine supplements 

So, out of all the creatine supplements on the market, which one is best? 

First of all, it is not advised to purchase liquid creatine monohydrate, as it is thought to be unstable and thus ineffective. Most creatine supplements come in powdered form. They don’t generally appear to be anything special, and just need mixing with water for you reap their benefits. 

  • Creatine monohydrate is simply powdered creatine, with no added thrills – but it works, plain and simple.
  • Creatine tablets or capsules can be purchased. These contain either powdered- or micronized forms of creatine monohydrate. These are simply more convenient for some than a shake. Whilst there are arguments that capsules and tablets are ineffective as they prevent the creatine from dissolving in water, there is no evidence behind such claims.
  • Creatine Ethyl Ester (CEE) is a more soluble form of creatine. It is thought that the creatine in this pairing can be more easily absorbed by your muscles and therefore that supplementing with this form of availability will enable faster loading.
  • Creapure is a form of micronized creatine monohydrate. This particular version is thought to be a pure form of high-quality creatine monohydrate, with has smaller particles than regular powder and can therefore both dissolve and take effect faster.


What is creatine? 

Creatine is a molecule found in the body which frees energy from cells for use, and helps rebuild the cellular form of energy (ATP).


What are the benefits of creatine? 

The main benefits of creatine include increases in explosive power, strength and muscle.


When should I take creatine? 

It is recommended to take creatine after your workout to replenish stores that are depleted as you train.


What dosage of creatine should I take? 

You should start with a loading phase of 20g per day for 5 days to saturate your muscles. After this, maintain with 3-5g per day.


What are the side effects of creatine? 

Side effects of creatine are uncommon, providing that you don’t have pre existing kidney problems. Creatine may also sometimes cause bloating as the muscles retain more water.


Take home message 

Creatine can be taken for a number of different goals, by different individuals, in different amounts and ways. It’s important to take this advice and find out what’s best for your body. Test out the methods for yourself and record your changes, after all, if the results aren’t what you desired, you can change and tailor your supplementation to suit your goals. 

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Our articles should be used for informational and educational purposes only and are not intended to be taken as medical advice. If you’re concerned, consult a health professional before taking dietary supplements or introducing any major changes to your diet.

Jacobs, I., Bleue, S., & Goodman, J. (1997). Creatine ingestion increases anaerobic capacity and maximum accumulated oxygen deficit. Canadian Journal of Applied Physiology, 22(3), 231-243.


Volek, J. S., Kraemer, W. J., Bush, J. A., Boetes, M., Incledon, T., Clark, K. L., & Lynch, J. M. (1997). Creatine supplementation enhances muscular performance during high-intensity resistance exercise. Journal of the American Dietetic Association, 97(7), 765-770.


Rockwell, J. A., Rankin, J. W., & Toderico, B. (2001). Creatine supplementation affects muscle creatine during energy restriction. Medicine and science in sports and exercise, 33(1), 61-68.


Earnest, C. P., Snell, P. G., Rodriguez, R., Almada, A. L., & Mitchell, T. L. (1995). The effect of creatine monohydrate ingestion on anaerobic power indices, muscular strength and body composition. Acta Physiologica Scandinavica, 153(2), 207.


Hultman, E., Soderlund, K., Timmons, J. A., Cederblad, G., & Greenhaff, P. L. (1996). Muscle creatine loading in men. Journal of Applied Physiology, 81(1), 232-237.


Kreider RB, Kalman DS, Antonio J, Ziegenfuss TN, Wildman R, Collins R, Candow DG, Kleiner SM, Almada AL, Lopez HL. International Society of Sports Nutrition position stand: safety and efficacy of creatine supplementation in exercise, sport, and medicine. J Int Soc SportsNutr. 2017 Jun 13;14:18. doi: 10.1186/s12970-017-0173-z. PMID: 28615996; PMCID: PMC5469049. 

 Powers ME, Arnold BL, Weltman AL, et al. Creatine Supplementation Increases Total Body Water Without Altering Fluid Distribution.J Athl Train. 2003;38(1):44-50. 

Liam Agnew

Liam Agnew

Sports Nutritionist and Personal Trainer

Liam is a certified sport nutritionist with the International Society of Sport Nutrition and is enrolled on the British Dietetics Association’s Sport and Exercise Nutrition register. He has a Bachelor’s of Science in Sport and Exercise Science and is graduate of the ISSN Diploma in Applied Sport and Exercise Nutrition.

Liam is an experienced personal trainer, helping clients reach their health and fitness goals with practical, evidence informed exercise and nutrition advice.

In his spare time Liam has competed in numerous powerlifting competitions and enjoys hill walking, football and expanding his recipe repertoire in the kitchen. Find out more about Liam's experience here.

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